2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt
2'-deoxyuridine 5'-triphosphate
CAS: 102814-08-4
Molecular Formula: C9H13N2O14P3.2Na
2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt - Names and Identifiers
| Name | 2'-deoxyuridine 5'-triphosphate |
| Synonyms | 2'-dUTP dUTP,3Na dUTP.Na3 Aids052149 Aids-052149 Trisodium 5'-dUTP 2'-Deoxyuracil 5'-triphosphate 2'-deoxyuridine 5'-triphosphate 2'-Deoxyuridine-5'-triphosphate,trisodium salt 2'-Deoxyuridine-5'-triphosphate trisodium salt 2'-Deoxyuridine-5'-Triphosphate Trisodium Salt 2'-deoxyuridine 5'-(tetrahydrogen triphosphate) 2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt |
| CAS | 102814-08-4 |
| EINECS | 999-999-2 |
| InChI | InChI=1/C9H15N2O14P3.Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17) |
2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt - Physico-chemical Properties
| Molecular Formula | C9H13N2O14P3.2Na |
| Molar Mass | 512.1 |
| Melting Point | >150o C (Dec.) |
| Specific Rotation(α) | 22 ° (C=1, H2O) |
| Water Solubility | Soluble in water. |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | White powder |
| Color | White |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Sensitive | Sensitive to air and easy to absorb moisture |
| MDL | MFCD00084701 |
| Use | 2′-Deoxyuridine 5′-triphosphate (dUTP) may be used to study the distribution, specificity and kinetics of deoxyuridine 5′-triphosphate nucleotidohydrolase(s). dUTPase are important enzymes that protect cells from the incorporation of dUTP into DNA.dU |
2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| HS Code | 29349990 |
2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]pentofuranosyl]-, monosodium salt - Introduction
2 '-deoxyuridine-5'-triphosphate trisodium salt is a nucleotide triphosphate compound. It is composed of 2 '-deoxyuridine and 5'-triphosphate. The compound is usually white crystal or powder, soluble in water.
2 '-deoxyuridine-5'-triphosphate trisodium salt has a wide range of applications in the field of biochemistry and molecular biology. One of them is to study the mechanism of DNA or RNA synthesis as an inhibitor. It is also used as a reagent in biotechnology and genetic engineering for the synthesis of specific DNA or RNA sequences. In addition, it is also used in pharmaceutical research and clinical fields.
The preparation of 2 '-deoxyuridine-5'-triphosphate trisodium salt usually involves two steps. First, 2 '-deoxyuridine (2'-deoxyuridine) is synthesized by chemical synthesis or by an enzymatic method; then, 2 '-deoxyuridine is reacted with a phosphate compound (e. g., triacetate phosphate) to generate 2'-deoxyuridine-5 '-triphosphate. Finally, 2 '-deoxyuridine-5'-triphosphate trisodium salt is formed by reaction with the appropriate sodium salt.
Regarding safety information, 2 '-deoxyuridine-5'-triphosphate trisodium salt is generally a low-toxic compound, but it is still necessary to pay attention to safety during operation and avoid contact with eyes, skin and inhalation. Use should wear protective gloves and eye protection, and operate in a well-ventilated place. If ingested or mistakenly entered the eye, immediately take appropriate first aid measures and seek medical help.
2 '-deoxyuridine-5'-triphosphate trisodium salt has a wide range of applications in the field of biochemistry and molecular biology. One of them is to study the mechanism of DNA or RNA synthesis as an inhibitor. It is also used as a reagent in biotechnology and genetic engineering for the synthesis of specific DNA or RNA sequences. In addition, it is also used in pharmaceutical research and clinical fields.
The preparation of 2 '-deoxyuridine-5'-triphosphate trisodium salt usually involves two steps. First, 2 '-deoxyuridine (2'-deoxyuridine) is synthesized by chemical synthesis or by an enzymatic method; then, 2 '-deoxyuridine is reacted with a phosphate compound (e. g., triacetate phosphate) to generate 2'-deoxyuridine-5 '-triphosphate. Finally, 2 '-deoxyuridine-5'-triphosphate trisodium salt is formed by reaction with the appropriate sodium salt.
Regarding safety information, 2 '-deoxyuridine-5'-triphosphate trisodium salt is generally a low-toxic compound, but it is still necessary to pay attention to safety during operation and avoid contact with eyes, skin and inhalation. Use should wear protective gloves and eye protection, and operate in a well-ventilated place. If ingested or mistakenly entered the eye, immediately take appropriate first aid measures and seek medical help.
Last Update：2024-04-09 21:01:54
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